Hello Bio/Amlodipine besylate/HB1214/50mg
商品编号：
HB1214-50mg
品牌：
hellobio
市场价：
¥1033.50
美元价：
795.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameAmlodipinebesylate
- ShortdescriptionL-typecalciumchannelblocker
- BIOLOGicaldescriptionL-typecalciumchannelblocker.DecreaseseNOSexpressionintheaorta.Showsantiproliferative,antihypertensive,antioxidant,anti-inflammatory,vasoprotectiveandneuroprotectiveactions.
- BiologicalactionBlocker
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylicacid3-ethyl5-methylesterbenzenesulfonate
- MolecularWeight567.05
- Chemicalstructure
![Amlodipine besylate [111470-99-6]](images/hellobio/201710/hb1214_2.png "Amlodipine besylate [111470-99-6]")
- MolecularFormulaC20H25ClN2O5.C6H6O3S
- CASNumber111470-99-6
- PubChemidentifier60496
- SMILESCCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O
- InChiInChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
- InChiKeyZPBWCRDSRKPIDG-UHFFFAOYSA-N
- MDLnumberMFCD00887594
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinwater(10mM)andinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforAmlodipinebesylate
AntiproliferativeeffectofCa2+channelblockersonhumanepidermoidcarcinomaA431cells.
YoshidaJetal(2003)EurJPharmacol472(1-2):23-31.PubMedID:12860469Calciumchannelblockadesexhibitanti-inflammatoryandantioxidativeeffectsbyaugmentationofendothelialnitricoxidesynthaseandtheinhibitionofangiotensinconvertingenzymeintheN(G)-nitro-L-argininemethylester-inducedhypertensiverataorta
TobaHetal(2005)HypertensRes28(8):689-700.PubMedID:16392774Calciumchannelblockadesexhibitanti-inflammatoryandantioxidativeeffectsbyaugmentationofendothelialnitricoxidesynthaseandtheinhibitionofangiotensinconvertingenzymeintheN(G)-nitro-L-argininemethylester-inducedhypertensiverataorta
TobaHetal(2005)HypertensRes28(8):689-700.PubMedID:16392774Neuroprotectiveeffectsofamlodipinebesylateandbenidipinehydrochlorideonoxidativestress-injuredneuralstemcells.
ChoiNYetal(2014)BrainRes1551:1-12.PubMedID:24440775
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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