Hello Bio/AMG 9810/HB1188/50mg
商品编号：
HB1188-50mg
品牌：
hellobio
市场价：
¥6103.50
美元价：
4695.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameAMG9810
- ShortdescriptionPotent,selective,competitiveTRPV1channelantagoNIST
- BIOLOGicaldescriptionPotent,selectiveandcompetitiveTRPV1channelantagonist(IC50valuesare24.5and85.6nMforhumanandratTRPV1respectively).CompetitivelyinhibitscapsaicinbindingtoratTRPV1.Displaysantihyperalgesiceffects.
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propenamide
- MolecularWeight337.42
- Chemicalstructure
![AMG 9810 [545395-94-6]](images/hellobio/201710/hb1188.png "AMG 9810 [545395-94-6]")
- MolecularFormulaC21H23NO3
- CASNumber545395-94-6
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- SolubilityoverviewsolubleinDMSO(50mM)orethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforAMG9810
AMG9810[(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide],anovelvanilloidreceptor1(TRPV1)antagonistwithantihyperalgesicproperties.
GavvaNRetal(2005)JPharmacolExpTher313(1):474-84.PubMedID:15615864Increasedacidresponsivenessinvagalsensoryneuronsinaguineapigmodelofeosinophilicesophagitis.
HuYetal(2014)AmJPhysiolGastrointestLiverPhysiol307(2):G149-57.PubMedID:24875100NorequirementofTRPV1inlong-termpotentiationorlong-termdepressionintheanteriorcingulatecortex.
LiuMGetal(2014)MolBrain7:27PubMedID:24708859
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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