Hello Bio/AMD 3100 octahydrochloride/HB2739/10mg
商品编号：
HB2739-10mg
品牌：
hellobio
市场价：
¥1482.00
美元价：
1140.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameAMD3100octahydrochloride
- ShortdescriptionPotent,selectiveCXCR4antagoNIST.Mobilizeshematopoieticstemcells.
- BIOLOGicaldescriptionPotentandselectiveCXCR4antagonist(IC50valuesare0.79and0.18atCXCR4andCCR2respectively).BlockstherouteofHIVentryintoT-cells.Showspotentanti-HIVactivityinvitroandinvivo.Alsomobilizeshematopoieticstemcells.
- AlternativenamesPlerixafor|JM3100
- BiologicalactionAntagonist
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1,1"-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane)octahydrochloride
- MolecularWeight794.48
- Chemicalstructure
![AMD 3100 octahydrochloride | JM 3100, Plerixafor [155148-31-5]](images/hellobio/201710/hb2739.png "AMD 3100 octahydrochloride | JM 3100, Plerixafor [155148-31-5]")
- MolecularFormulaC28H54N8.8HCl
- CASNumber155148-31-5
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- Solubilityoverviewsolubleinwater(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforAMD3100octahydrochloride
Synthesisandstructure-activityrelationshipsofphenyleNEBis(methylene)-linkedbis-tetraazamacrocyclesthatinhibitHIVreplication.Effectsofmacrocyclicringsizeandsubstituentsonthearomaticlinker.
Bridgeretal(1995)JMedChem38(2):366-78PubMedID:7830280CharacterizationofthemolecularpharmacologyofAMD3100:aspecificantagonistoftheG-proteincoupledchemokinereceptor,CXCR4.
Frickeretal(2006)BiochemPharmacol72(5):588-96PubMedID:16815309EffectivemobilizationofhematopoieticProgenitorcellsinG-CSFmobilizationdefectiveCD26-/-micethroughAMD3100-induceddisruptionoftheCXCL12-CXCR4axis.
Paganessi(2011)ExpHematol39(3):384-90PubMedID:21168468
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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