Hello Bio/Amantadine hydrochloride/HB0109/5g
市场价：
¥409.50
美元价：
315.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameAmantADInehydrochloride
- ShortdescriptionNon-competitiveNMDAreceptorantagoNIST
- BIOLOGicaldescriptionNon-competitiveNMDAreceptorantagonist(IC50=approx35µM).MayalsoblockSEROtoninuptake.Showsantiviraleffectsinvivo.Actsasadopaminergicagentwithanti-parkinsonianeffects;suppressesL-DOPA-induceddyskinesia.InducesD2andD3receptorup-regulation.Blood-brainbarrierpermeable.
- BiologicalactionAntagonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameAdamantan-1-aminehydrochloride
- MolecularWeight187.71
- Chemicalstructure
![Amantadine [665-66-7]](images/hellobio/201710/hb0109.png "Amantadine [665-66-7]")
- MolecularFormulaC10H17N.HCl
- CASNumber665-66-7
- PubChemidentifier64150
- SMILESC1C2CC3CC1CC(C2)(C3)N.Cl
- InChiInChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H
- InChiKeyWOLHOYHSEKDWQH-UHFFFAOYSA-N
- MDLnumberMFCD00074723
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinwater(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforAmantadinehydrochloride
AmantadineinhibitsNMDAreceptorsbyacceleratingchannelclosureduringchannelblock.
Blanpiedetal(2005)JNeurosci25(13):3312-22PubMedID:15800186EffectofcombinedtreatmentwithimipramineandamantadineonthecentraldopamineD2andD3receptorsinrats.
Rogozetal(2003)JPhysiolPharmacol.54(2):257-70PubMedID:12832726FunctionalstudiesindicateamantadinebindstotheporeoftheinfluenzaAvirusM2proton-selectiveionchannel.
Jingetal(2008)ProcNatlAcadSciUSA105(31):10967-72PubMedID:18669647
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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