你好生物/α-银环蛇毒素/HB2038/
市场价：
¥721.50
美元价：
555.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Nameα-Bungarotoxin
- Shortdescriptionα7subtypeselectivenAChRantagoNIST
- BIOLOGicaldescription
IrreversIBLe,highaffinitynicotinicacethylcholinereceptor(nAChR)antagonist.Neurotoxin.Showssubtypeselectivityforα7overα3β4receptors.
Showsactivityattheheteromericmusclereceptors(αβγδorαβδεsubunits)andneuronalsubtypes(α7,α8,α9subunits,(IC50valuesare1.6nMand>3μMrespectively).
Preventsopeningofnicotinicreceptor-associatedionchannelsandblocksneuromusculartransmission.Additionallyactsasanimagingtoolforfluorophore-labelingstudies.
- Alternativenamesα-BTX,α-Bgtx,α-BuTX,BGT
- BiologicalactionAntagonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname
- MolecularWeight7984
- MolecularFormulaC338H529N97O105S11
- CASNumber11032-79-4
- SourceBungarusmulticinctus
StoringandUsingYourProduct
- Storageinstructions-20°C(dessicate)
- SolubilityoverviewSolubleinwater
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesforα-Bungarotoxin
Snakeneurotoxinα-bungarotoxinisanantagonistatnativeGABA(A)receptors.
Hannanetal(2015)Neuropharmacology93:28-40PubMedID:25634239Inter-residuecouplingcontributestohigh-affinitysubtype-selectivebindingofα-bungarotoxintonicotinicreceptors.
Sineetal(2013)BiochemJ454(2):311-21PubMedID:23802200Neuronalacetylcholinereceptorsthatbindalpha-bungarotoxinwithhighaffinityfunctionasligand-gatedionchannels.
Zhangetal(1994)Neuron12(1):167-77PubMedID:7507338Identificationofregionsinvolvedinthebindingofalpha-bungarotoxintothehumanalpha7neuronalnicotinicacetylcholinereceptorusingsyntheticpeptides.
Marinouetal(12614199)BiochemJ372:543-54PubMedID:12614199
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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