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商品详细Hello Bio/AG 490/HB1424/50mg
Hello Bio/AG 490/HB1424/50mg
Hello Bio/AG 490/HB1424/50mg
商品编号: HB1424-50mg
品牌: hellobio
市场价: ¥3568.50
美元价: 2745.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Productoverview

  • Name
    AG490
  • Shortdescription
    SelectiveEGFreceptortyrosinekinaseinhibitor
  • BIOLOGicaldescription
    SelectiveEGFreceptortyrosinekinaseinhibitor.InhibitsEGFRandErbB2(IC50valuesare2and13.5µMrespectively).InhibitsJAK2,JAK3/STAT,JAK3/AP-1andJAK3/MAPKsignalingpathways.InhibitsIL-2-inducedTcellproliferation.Showsanti-canceractions.
  • Biologicalaction
    Inhibitor
  • Purity
    >99%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide
  • MolecularWeight
    294.31
  • Chemicalstructure
    AG 490 [133550-30-8]
  • MolecularFormula
    C17H14N2O3
  • CASNumber
    133550-30-8

StoringandUsingYourProduct

  • Storageinstructions
    roomtemperature
  • Solubilityoverview
    solubleinDMSO(100mM)orethanol(20mM)
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforAG490

  • JAK3,STAT,andMAPKsignalingpathwaysasnovelmoleculartargetsforthetyrphostinAG-490regulationofIL-2-mediatedTcellresponse.

    WangLHetal(1999)JImmunol162(7):3897-904.
    PubMedID:10201908
  • InhibitionofacutelymphoblasticleukaemiabyaJak-2inhibitor.

    MeydanNetal(1996)Nature379(6566):645-8.
    PubMedID:8628398
  • Tyrphostins.2.Heterocyclicandalpha-substitutedbenzylidenemalononitriletyrphostinsaspotentinhibitorsofEGFreceptorandErbB2/neutyrosinekinases.

    GazitAetal(1991)JMedChem34(6):1896-907.
    PubMedID:1676428
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor,  NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632,  SB 431542 DAPT.