
Hello Bio/AG 490/HB1424/50mg
商品编号:
HB1424-50mg
品牌:
hellobio
市场价:
¥3568.50
美元价:
2745.00
产品分类:
酸碱缓冲液
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Productoverview
- NameAG490
- ShortdescriptionSelectiveEGFreceptortyrosinekinaseinhibitor
- BIOLOGicaldescriptionSelectiveEGFreceptortyrosinekinaseinhibitor.InhibitsEGFRandErbB2(IC50valuesare2and13.5µMrespectively).InhibitsJAK2,JAK3/STAT,JAK3/AP-1andJAK3/MAPKsignalingpathways.InhibitsIL-2-inducedTcellproliferation.Showsanti-canceractions.
- BiologicalactionInhibitor
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide
- MolecularWeight294.31
- Chemicalstructure
- MolecularFormulaC17H14N2O3
- CASNumber133550-30-8
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(20mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforAG490
JAK3,STAT,andMAPKsignalingpathwaysasnovelmoleculartargetsforthetyrphostinAG-490regulationofIL-2-mediatedTcellresponse.
WangLHetal(1999)JImmunol162(7):3897-904.PubMedID:10201908InhibitionofacutelymphoblasticleukaemiabyaJak-2inhibitor.
MeydanNetal(1996)Nature379(6566):645-8.PubMedID:8628398Tyrphostins.2.Heterocyclicandalpha-substitutedbenzylidenemalononitriletyrphostinsaspotentinhibitorsofEGFreceptorandErbB2/neutyrosinekinases.
GazitAetal(1991)JMedChem34(6):1896-907.PubMedID:1676428
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们