Hello Bio/A 967079/HB1156/25mg
商品编号：
HB1156-5mg
品牌：
hellobio
市场价：
¥936.00
美元价：
720.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameA967079
- ShortdescriptionPotent,selectiveTRPA1channelblocker
- BIOLOGicaldescriptionPotentandselectiveTRPA1channelblocker(IC50valuesare67and289nMforhumanTRPA1andratTRPA1channelsrespectively).Exhibitsgreaterthan1000-foldselectivityforTRPA1overotherTRPchannels.Exhibitsanalgesicactions.DoesnotalterbodytemperatureunlikeotherTRPV1channelblockers.
- BiologicalactionBlocker
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-oneoxime
- MolecularWeight207.24
- Chemicalstructure
![A 967079 [1170613-55-4]](images/hellobio/201710/hb1156.png "A 967079 [1170613-55-4]")
- MolecularFormulaC12H14FNO
- CASNumber1170613-55-4
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforA967079
SelectiveblockadeofTRPA1channelattenuatespathologicalpainwithoutalteringnoxiouscoldsensationorbodytemperatureregulation.
ChenJetal(2011)Pain152(5):1165-72.PubMedID:21402443TRPA1modulationofspontaneousandmechanicallyevokedfiringofspinalneuronsinuninjured,osteoarthritic,andinflamedrats.
McGaraughtySetal(2010)MolPain6:14PubMedID:20205719TRPV1andTRPA1antagoNISTspreventthetransitionofacutetochronicinflammationandpaininchronicpancreatitis.
SchwartzESetal(2013)JNeurosci33(13):5603-11.PubMedID:23536075
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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