Hello Bio/A 83-01/HB3218/25mg
商品编号：
HB3218-5mg
品牌：
hellobio
市场价：
¥1209.00
美元价：
930.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameA83-01
- ShortdescriptionSelectiveTGF-βRI(ALK5),ALK4andALK7inhibitor.Maintainshumaninducedpluripotentstemcell(hiPSC)selfrenewal.
- BIOLOGicaldescriptionSelectiveTGF-βRI(ALK5),ALK4andALK7inhibitor(IC50valuesare12,45and7.5nMatALK5,ALK4andALK7respectively).Inhibitsratinducedpluripotentstemcells(rIPSCs)andmaintainshiPSCselfrenewal.
- AlternativenamesA83
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
- MolecularWeight421.52
- MolecularFormulaC25H19N5S
- CASNumber909910-43-6
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewsolubleinDMSO(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforA83-01
TheALK-5inhibitorA-83-01inhibitsSmadsignalingandepithelial-to-mesenchymaltransitionbytransforminggrowthfactor-beta.
Tojoetal(2005)CancerSci96(11):791-800PubMedID:16271073Briefreport:combinedchemicaltreatmentenablesOct4-inducedreprogrammingfrommouseembryonicfibroblasts.
Yuanetal(2011)201129(3):549-53PubMedID:21425417Generationofratandhumaninducedpluripotentstemcellsbycombininggeneticreprogrammingandchemicalinhibitors.
Lietal(2009)CellStemCell4(1):16-9PubMedID:19097958
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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