Hello Bio/A 484954/HB0093/100mg
市场价：
¥21118.50
美元价：
16245.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameA484954
- ShortdescriptionPotent,selectiveeEF-2K/CaMKIIIinhibitor
- BIOLOGicaldescriptionPotentandselectiveeukaryoticelongationfactor-2kinase(eEF-2K/CAMKIII)inhibitor(IC50=420nM).ReduceseEF-2phosphorylation.
- BiologicalactionInhibitor
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide
- MolecularWeight289.29
- Chemicalstructure
![A 484954 [142557-61-7]](images/hellobio/201710/hb0093.png "A 484954 [142557-61-7]")
- MolecularFormulaC13H15N5O3
- CASNumber142557-61-7
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(10mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforA484954
1-Benzyl-3-cetyl-2-methylimidazoliumiodide(NH125)inducesphosphorylationofeukaryoticelongationfactor-2(eEF2):acautionarynoteontheanticancermechanismofaneEF2kinaseinhibitor.
ChenZetal(2011)JBiolChem286(51):43951-8.PubMedID:22020937Synthesisandbiologicalevaluationofpyrido[2,3-d]pyrimidine-2,4-dionederivativesaseEF-2Kinhibitors.
EdupugantiRetal(2014)BioorgMedChem22(17):4910-6.PubMedID:25047940Eukaryoticelongationfactor2kinasecontrolsproliferationandmigrationofvascularsmoothmusclecells.
UsuiTetal(2014)ActaPhysiol(Oxf):PubMedID:25069823
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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