你好Bio/VU 29/HB0642/
市场价：
¥955.50
美元价：
735.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameVU29
- ShortdescriptionPotentmGlu5positiveallostericmodulator
- BIOLOGicaldescriptionPotentmGlu5receptorpositiveallostericmodulator(EC50=9nM).SelectivelypotentiatesmGlu5overmGlu1andmGlu2receptors(EC50valuesare557nMand1.51µMformGlu1andmGlu2receptorsrespectively).ShowsagoNISTicpropertiesforN-TerminaltruncatedmGlu5receptor.CDPPBanalog.
- BiologicalactionPAM
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide
- MolecularWeight384.39
- Chemicalstructure
![VU 29 [890764-36-0]](images/hellobio/201710/hb0642.png "VU 29 [890764-36-0]")
- MolecularFormulaC22H16N4O3
- CASNumber890764-36-0
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforVU29
Interactionofnovelpositiveallostericmodulatorsofmetabotropicglutamatereceptor5withthenegativeallostericantagonistsiteisrequiredforpotentiationofreceptorresponses.
ChenYetal(2007)MolPharmacol71(5):1389-98.PubMedID:17303702SubstituenteffectsofN-(1,3-diphenyl-1H-pyrazol-5-yl)benzamidesonpositiveallostericmodulationofthemetabotropicglutamate-5receptorinratcorticalastrocytes.
dePaulisTetal(2006)JMedChem49(11):3332-44.PubMedID:16722652mGluR5positiveallostericmodulatorsfacilitatebothhippocampalLTPandLTDandenhancespatiallearning.
AyalaJEetal(2009)Neuropsychopharmacology34(9):2057-71.PubMedID:19295507
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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