你好Bio/VU 0357017盐酸盐/HB1498/50mg
商品编号：
HB1498-50mg
品牌：
hellobio
市场价：
¥5128.50
美元价：
3945.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameVU0357017hydrochloride
- ShortdescriptionPotent,selectiveM1receptorallostericagoNIST
- BIOLOGicaldescriptionPotentandselectiveM1muscarinicreceptorallostericagonist(EC50=198nM).BindstotheorthostericAChsiteathighconcentrationstoactasanantagonist.Reversescontextualfearconditioningdeficits.Showscognitiveenhancingactions.Blood-brainbarrierpermeable.
- BiologicalactionAgonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylicacidethylesterhydrochloride
- MolecularWeight369.89
- Chemicalstructure
![VU 0357017 hydrochloride [1135242-13-5]](images/hellobio/201710/hb1498.png "VU 0357017 hydrochloride [1135242-13-5]")
- MolecularFormulaC18H27N3O3.HCl
- CASNumber1135242-13-5
StoringandUsingYourProduct
- Storageinstructions+4°C
- Solubilityoverviewsolubleinwater(25mM)orDMSO(5mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforVU0357017hydrochloride
Discoveryandcharacterizationofnovelsubtype-selectiveallostericagonistsfortheinvestigationofM(1)receptorfunctioninthecentralnervoussystem.
LeboisEPetal(2010)ACSChemNeurosci1(2):104-121.PubMedID:21961051NovelallostericagonistsofM1muscarinicacetylcholinereceptorsinducebrainregion-specificresponsesthatcorrespondwithbehavioraleffectsinanimalmodels.
DigbyGJetal(2012)JNeurosci32(25):8532-44.PubMedID:22723693FurtherexplorationofM₁allostericagonists:subtlestructuralchangesabolishM₁allostericagonismandresultinpan-mAChRorthostericantagonism.
ShefflerDJetal(2013)BioorgMedChemLett23(1):223-7.PubMedID:23200253
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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