你好Bio/VU 0357017盐酸盐/HB1498/10mg
商品编号：
HB1498-10mg
品牌：
hellobio
市场价：
¥1345.50
美元价：
1035.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameVU 0357017 hydrochloride
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Short descriptionPotent, selective M1 receptor allosteric agonist
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Biological descriptionPotent and selective M1 muscarinic receptor allosteric agonist (EC50 = 198 nM). Binds to the orthosteric ACh site at high concentrations to act as an antagonist. Reverses contextual fear conditioning deficits. Shows cognitive enhancing actions. Blood-brain barrier permeable.
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Biological actionAgonist
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Purity>98%
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Properties
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Chemical name4-[[2-[(2-Methylbenzoyl)amino]ethyl ]amino]-1-piperidinecarboxylic acid ethyl ester hydrochloride
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Molecular Weight369.89
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Chemical structure
![VU 0357017 hydrochloride [1135242-13-5]](images/hellobio/201710/hb1498.png "VU 0357017 hydrochloride [1135242-13-5]")
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Molecular FormulaC18H27N3O3.HCl
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CAS Number1135242-13-5
Storing and Using Your Product
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Storage instructions+4°C
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Solubility overviewsoluble in water (25mM) or DMSO (5mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for VU 0357017 hydrochloride
Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.
Lebois EP et al (2010) ACS Chem Neurosci 1(2) : 104-121.PubMedID: 21961051Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models.
Digby GJ et al (2012) J Neurosci 32(25) : 8532-44.PubMedID: 22723693Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.
Sheffler DJ et al (2013) Bioorg Med Chem Lett 23(1) : 223-7.PubMedID: 23200253
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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