Hello Bio/SKF 81297 hydrobromide/HB1858/
市场价：
¥2086.50
美元价：
1605.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameSKF 81297 hydrobromide
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Short descriptionD1-like receptor agonist
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Biological descriptionD1-like receptor agonist (Ki values are 2.2 and >1000 nM at D1 and D2 receptors respectively). Shows ~500 times greater affinity for D1 over D2. Stimulates motor behaviour. Active in vivo.
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Biological actionAgonist
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Purity>98%
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Properties
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Chemical name(±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide
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Molecular Weight370.67
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Chemical structure
![SKF 81297 hydrobromide [67287-39-2]](images/hellobio/201710/hb1858.png "SKF 81297 hydrobromide [67287-39-2]")
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Molecular FormulaC16H16ClNO2.HBr
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CAS Number67287-39-2
Storing and Using Your Product
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Storage instructions+4°C (desiccate)
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Solubility overviewSoluble in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for SKF 81297 hydrobromide
Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6
Yamamoto N et al (2008) Neuroscience 154(3) : 1088-99.PubMedID: 18495353Dopamine D1 activation shortens the duration of phases in stereotyped grooming sequences.
Matell MS et al (2006) Behav Processes 71(2-3) : 241-9.PubMedID: 16246504The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys.
Vermeulen RJ et al (1993) Eur J Pharmacol 235(1) : 143-7.PubMedID: 8100193Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.
Cai JX et al (1997) J Pharmacol Exp Ther 283(1) : 183-9.PubMedID: 9336323
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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