Hello Bio/SKF 81297 hydrobromide/HB1858/10mg
商品编号：
HB1858-10mg
品牌：
hellobio
市场价：
¥1989.00
美元价：
1530.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSKF81297hydrobromide
- ShortdescriptionD1-likereceptoragoNIST
- BIOLOGicaldescriptionD1-likereceptoragonist(Kivaluesare2.2and>1000nMatD1andD2receptorsrespectively).Shows~500timesgreateraffinityforD1overD2.Stimulatesmotorbehaviour.Activeinvivo.
- BiologicalactionAgonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepinehydrobromide
- MolecularWeight370.67
- Chemicalstructure
![SKF 81297 hydrobromide [67287-39-2]](images/hellobio/201710/hb1858.png "SKF 81297 hydrobromide [67287-39-2]")
- MolecularFormulaC16H16ClNO2.HBr
- CASNumber67287-39-2
StoringandUsingYourProduct
- Storageinstructions+4°C(desiccate)
- SolubilityoverviewSolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSKF81297hydrobromide
Time-courseofSKF-81297-inducedincreaseinglutamicaciddecarboxylase65and67mRNAlevelsinstriatonigralneuronsanddecreaseinGABA(A)receptoralpha1subunitmRNAlevelsinthesubstantianigra,parsreticulata,inadultratswithaunilateral6
YamamotoNetal(2008)Neuroscience154(3):1088-99.PubMedID:18495353DopamineD1activationshortensthedurationofphasesinstereotypedgroomingsequences.
MatellMSetal(2006)BehavProcesses71(2-3):241-9.PubMedID:16246504TheselectivedopamineD1receptoragonist,SKF81297,stimulatesmotorbehaviourofMPTP-lesionedmonkeys.
VermeulenRJetal(1993)EurJPharmacol235(1):143-7.PubMedID:8100193Dose-dependenteffectsofthedopamineD1receptoragonistsA77636orSKF81297onspatialworkingmemoryinagedmonkeys.
CaiJXetal(1997)JPharmacolExpTher283(1):183-9.PubMedID:9336323
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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