Hello Bio/SKF 38393 hydrochloride/HB6111/100mg
商品编号：
HB6111-100mg
品牌：
hellobio
市场价：
¥975.00
美元价：
750.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSKF38393hydrochloride
- ShortdescriptionPrototypic,selectiveD1-likereceptorpartialagoNIST
- BIOLOGicaldescription
Prototypic,selectiveD1-likedopaminereceptorpartialagonist(Kivaluesare1and~0.5nMatD1-likereceptors(D1andD5)and~150,~5000and~1000nMatD2-likereceptors(D2,D3andD4)respectively).Hydrochloridesalt.
SKF38393facilitateslongtermpotentiation(LTP)viaD1andD5activationandhasalsobeenshowntopresynapticallystimulateglutamatereleaseinthehippocampus.AdditionallyactivatestheHPAaxistoincreaseACTHandcorticosteronelevels.
Showsproconvulsantandanorexiceffects.
Bloodbrainbarrierpermeable.
Activeinvivo.
SKF38393hydrobromidealsoavailable. - AlternativenamesSKF38393
- BiologicalactionAgonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diolhydrochloride
- MolecularWeight291.77
- Chemicalstructure
![SKF 38393 [62717-42-2]](images/hellobio/201710/hb6111.png "SKF 38393 [62717-42-2]")
- MolecularFormulaC16H17NO2.HCl
- CASNumber62717-42-4
- PubChemidentifier147514
- SMILESC1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl
- SourceSynthetic
- InChiInChI=1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H
- InChiKeyYEWHJCLOUYPAOH-UHFFFAOYSA-N
- MDLnumberMFCD00069248
- AppearanceWhiteSolid
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewSolubleinwater(50mM,warming)andinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSKF38393hydrochloride
CloningofthegeneforahumandopamineD5receptorwithhigheraffinityfordopaminethanD1.
SunaharaRKetal(1991)Nature350(6319):614-9.PubMedID:1826762TheanorecticeffectofSK&F38393,aselectivedopamineD1receptoragonist:amicrostructuralanalysisoffeedingandrelatedbehaviour.
CooperSJetal(1990)Psychopharmacology(Berl):100(2)PubMedID:1968277EffectsofquinpiroleandSKF38393aloneandincombinationinsquirrelmonkeystrainedtodiscriminatecocaine.
KatzJLetal(1992)Psychopharmacology(Berl)107(2-3):217-20.PubMedID:1352052Dopaminereceptorpharmacology.
SeemanandVanTol(1994)TrendsPharmacolSci.15(5):264-70PubMedID:7940991D1/5receptor-mediatedenhancementofLTPrequiresPKA,Srcfamilykinases,andNR2B-containingNMDARs.
StramielloandWagner(2008)Neuropharmacology55(5):871-7PubMedID:18644393
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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