Hello Bio/SKA 31/HB1050/10mg
商品编号：
HB1050-10mg
品牌：
hellobio
市场价：
¥1072.50
美元价：
825.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSKA31
- ShortdescriptionKCa3.1channel/KCa2channelsubfamilyactivator
- BIOLOGicaldescriptionKCa3.1channel(EC50=260nM)andKCa2subfamilyactivator(EC50valuesare2.9,1.9and2.9µMforKCa2.1KCa2.2andKCa2.3channelsrespectively).Displaysvasodilationandantihypertensiveproperties.
- BiologicalactionActivator
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameNaphtho[1,2-d]thiazol-2-ylamine
- MolecularWeight200.26
- Chemicalstructure
![SKA 31 [40172-65-4]](images/hellobio/201710/hb1050.png "SKA 31 [40172-65-4]")
- MolecularFormulaC11H8N2S
- CASNumber40172-65-4
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSKA31
ActivationofKCa3.1bySKA-31inducesarteriolardilatationandlowersbloodpressureinnormo-andhypertensiveconnexin40-deficientmice.
RadtkeJetal(2013)BrJPharmacol170(2):293-303.PubMedID:23734697Naphtho[1,2-d]thiazol-2-ylamine(SKA-31),anewactivatorofKCa2andKCa3.1potassiumchannels,potentiatestheendothelium-derivedhyperpolarizingfactorresponseandlowersbloodpressure.
SankaranarayananAetal(2009)MolPharmacol75(2):281-95.PubMedID:18955585SKA-31,anovelactivatorofSK(Ca)andIK(Ca)channels,increasescoronaryflowinmaleandfemalerathearts.
MishraRCetal(2013)CardiovascRes97(2):339-48.PubMedID:23118129
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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