你好Bio/Salvinorin B（SALB）/HB4887/1mg
商品编号：
HB4887-1mg
品牌：
hellobio
市场价：
¥838.50
美元价：
645.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameSalvinorinB(SALB)
- ShortdescriptionPotent,selectiveKORDDREADDactivator
- BIOLOGicaldescription
SalvinorinB(SALB)isapharmacologicallyinertligandthatpotentlyandselectivelyactivatestheKORD(theκ-opioiddesignerreceptor(DREADD))(EC50=11.8nM).
SalvinorinB(SALB)is~100-foldselectivefortheKORDDREADDoverhumanκopioidreceptorandothertargetsandshowsgoodCNSpenetrABIlity.
ActivationofKORDbySalvinorinB(SALB)inducesneuronalinhibitionandmodifiesbehaviourinvivo.
SalvinorinB(SALB)canbeusedinmicealsoexpressingClozapineN-Oxide(CNO)responsiveDREADDS,toallowbi-directionalmanipulationofneuralcircuits.
ClozapineN-Oxide(CNO)alsoavailable. - AlternativenamesSALB,DivinorinB
- BiologicalactionActivator
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylicacidmethylester
- MolecularWeight390.43
- Chemicalstructure
![Salvinorin B | [92545-30-7]](images/hellobio/201710/hb4887.png "Salvinorin B | [92545-30-7]")
- MolecularFormulaC21H26O7
- CASNumber92545-30-7
- PubChemidentifier11440685
- SMILESC[C@@]12CC[C@H]3C(=O)O[C@@H](C[C@@]3([C@H]1C(=O)[C@H](C[C@H]2C(=O)OC)O)C)C4=COC=C4
- SourceExtractedfromsalviadivinorum
- InChiInChI=1S/C21H26O7/c1-20-6-4-12-19(25)28-15(11-5-7-27-10-11)9-21(12,2)17(20)16(23)14(22)8-13(20)18(24)26-3/h5,7,10,12-15,17,22H,4,6,8-9H2,1-3H3/t12-,13-,14-,15-,17-,20-,21-/m0/s1
- InChiKeyBLTMVAIOAAGYAR-CEFSSPBYSA-N
- MDLnumberMFCD16036232
- AppearanceOff-whitesolid
StoringandUsingYourProduct
- Storageinstructions-20°C
- SolubilityoverviewSolubleinDMSO(20mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforSalvinorinB(SALB)
ANewDREADDFacilitatestheMultiplexedChemogeneticInterrogationofBehavior.
Vardyetal(2015)Neuron.86(4):936-46.PubMedID:25937170DREADDS:Useandapplicationinbehavioralneuroscience.
Smithetal(206)BehavNeurosci130(2):137-55.PubMedID:26913540BehavioralandPhysiologicalEffectsofaNovelKappa-OpioidReceptor-BasedDREADDinRats.
Marchantetal(2016)Neuropsychopharmacology41(2):402-9.PubMedID:26019014AntinociceptiveandhypothermiceffectsofSalvinorinAareabolishedinanovelstrainofkappa-opioidreceptor-1knockoutmice.
AnsonoffMAetal(2006)JPharmacolExpTher318(2)::641-8.PubMedID:16672569
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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