你好生物/树脂毒素/HB1185/5mg
市场价：
¥8463.00
美元价：
6510.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameResiniferatoxin
- ShortdescriptionPotentTRPV1channelagoNIST
- BIOLOGicaldescriptionCapsaicinanalogue.PotentTRPV1channelagonist(Ki=42.5pM).Showsactionsagainstneuropathicpainandinhibitsinflammatoryhyperalgesia.Showsmusculoskeletalhyperalgesiceffects.
- BiologicalactionAgonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneacetate
- MolecularWeight628.72
- Chemicalstructure
![Resiniferatoxin [57444-62-9]](images/hellobio/201710/hb1185.png "Resiniferatoxin [57444-62-9]")
- MolecularFormulaC37H40O9
- CASNumber57444-62-9
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforResiniferatoxin
Distinctstructure-activityrelationsforstimulationof45Cauptakeandforhighaffinitybindinginculturedratdorsalrootganglionneuronsanddorsalrootganglionmembranes.
AcsGetal(1996)BrainResMolBrainRes35(1-2):173-82.PubMedID:8717353Resiniferatoxin(RTX)causesauniquelyprotractedmusculoskeletalhyperalgesiainmicebyactivationofTRPV1receptors.
ABDelhamidREetal(2013)JPain14(12):1629-41.PubMedID:24188863Perineuralresiniferatoxinselectivelyinhibitsinflammatoryhyperalgesia.
NeubertJKetal(2008)MolPain4:3PubMedID:18199335
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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