Hello Bio/L-Quisqualic acid/HB0387/5mg
商品编号：
HB0387-5mg
品牌：
hellobio
市场价：
¥1833.00
美元价：
1410.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameL-Quisqualic acid
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Short descriptionAMPA receptor agonist / group I mGlu agonist
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Biological description
AMPA receptor agonist / group I mGlu agonist.
Sensitizes neurons to excitatory amino acid analogues such as L-AP4, L-AP6 and L-AbetaH ("the Quis effect").
Can act as an excitotoxin and is used to lesion areas of the brain in rat models.
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Biological actionAgonist
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Purity>99%
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Properties
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Chemical name(L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
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Molecular Weight189.13
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Chemical structure
![L-Quisqualic acid [52809-07-1]](images/hellobio/201710/hb0387.png "L-Quisqualic acid [52809-07-1]")
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Molecular FormulaC5H7N3O5
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CAS Number52809-07-1
Storing and Using Your Product
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Storage instructionsroom temperature
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Solubility overviewsoluble in NaOH(aq) (100mM, 1eq. NaOH) or water (10mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for L-Quisqualic acid
L-Quisqualic acid transport into hippocampal neurons by a cystine-sensitive carrier is required for the induction of quisqualate sensitization.
Chase LA et al (2001) Neuroscience 106(2) : 287-301.PubMedID: 11566501C-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid: a study in adult and aged animals.
Giovannelli L et al (1998) J Neural Transm 105(8-9) : 935-48.PubMedID: 9869327Prolonged nociceptive responses to hind paw formalin injection in rats with a spinal cord injury.
Lee JW et al (2008) Neurosci Lett 439(2) : 212-5.PubMedID: 18524486Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus.
Littman L et al (1995) Neuropharmacology 34(8) : 829-41.PubMedID: 8532164
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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