你好Bio/PPT/HB2499/10mg
商品编号：
HB2499-10mg
品牌：
hellobio
市场价：
¥1716.00
美元价：
1320.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NamePPT
- ShortdescriptionSelectiveERαestrogenreceptoragoNIST
- BIOLOGicaldescriptionSelectiveERαestrogenreceptoragonist(Kdvaluesare2and1000nMatERαandERβrespectively).Displaysa410-foldhigherselectivityforERαoverERβ.Showsneuroprotectiveeffects.Activeinvivo.
- BiologicalactionAgonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4,4",4""-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol
- MolecularWeight386.45
- Chemicalstructure
![PPT [263717-53-9]](images/hellobio/201710/hb2499.png "PPT [263717-53-9]")
- MolecularFormulaC24H22N2O3
- CASNumber263717-53-9
- PubChemidentifier6095481
- SMILESCCCC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O
- InChiInChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,25,28-29H,2-3H2,1H3
- InChiKeyUOSWGERPQQOSHS-UHFFFAOYSA-N
- MDLnumberMFCD03453628
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewSolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforPPT
Pharmacokineticsoftheestrogenreceptorsubtype-selectiveligands,PPTandDPN:quantificationusingUPLC-ES/MS/MS.
SepehrEetal(2012)JPharmBiomedAnal71:119-26.PubMedID:22981216EstrogenreceptorsubtypesalphaandbetacontributetoneuroprotectionandincreasedBcl-2expressioninprimaryhippocampalneurons.
ZhaoLetal(2004)BrainRes1010(1-2):22-34.PubMedID:15126114ThepossIBLeroleofestrogenandselectiveestrogenreceptormodulatorsinaratmodelofParkinson"sdisease.
BarakaAMetal(2011)LifeSci88(19-20):879-85.PubMedID:21420980
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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