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Hello Bio/Perlapine hydrochloride (water soluble)/HB6126/50mg
Hello Bio/Perlapine hydrochloride (water soluble)/HB6126/50mg
商品编号：
HB6126-50mg
品牌：
hellobio
市场价：
¥4680.00
美元价：
3600.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NamePerlapine hydrochloride (water soluble)
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Short descriptionNovel, potent and selective hM3Dq DREADD receptor agonist. Water soluble.
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Biological description
Perlapine hydrochloride is a water soluble version of perlapine which is a novel, potent and selective, non-CNO (Clozapine N Oxide) hM3Dq DREADD receptor agonist (EC50 = 2.8 nM). Perlapine also activates the inhibitory hM2Di and hM4Di Gi-DREADDs.
Perlapine shows >10,000-fold selectivity for hM3Dq over hM3 muscarinic receptor.Unlike CNO, perlapine is especially suited for translational studies. Perlapine also acts as a sleep inducing, hypnotic agent.
Clozapine N-oxide (CNO) (water soluble), Compound 21, Salvinorin B (SalB) and perlapine freebase are also available. -
Alternative namesNSC291840 hydrochloride
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Biological actionActivator
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Purity>98%
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Properties
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Chemical name6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine dihydrochloride
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Molecular Weight360.3
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Chemical structure
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Molecular FormulaC19H21N3.2HCl
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SMILESCN1CCN(CC1)C2=NC3=CC=CC=C3CC4=CC=CC=C42.Cl.Cl
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SourceSynthetic
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AppearanceWhite solid
Storing and Using Your Product
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Storage instructionsRoom temperature
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Solubility overviewSoluble in water (100 mM)
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HandlingHydroscopic solid, contact with air may cause material to become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar.
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
References for Perlapine hydrochloride (water soluble)
The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs.
Chen et al (2015) ACS Chem Neurosci 6(3) : 476-84PubMedID: 255878886-(4-Methyl-1-piperazinyl)morphanthridine (Perlapine), a new tricyclic compound with sedative and sleep-promoting properties. A pharmacological study.
Stille et al (1973) Psychopharmacologia 24(4) : 325-37PubMedID: 4695567DREADDs for Neuroscientists.
Roth Bl (2016) Neuron 89(4) : 683-94PubMedID: 26889809
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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