你好Bio/Perlapine盐酸盐（水溶性）/HB6126/1mg
商品编号：
HB6126-1mg
品牌：
hellobio
市场价：
¥780.00
美元价：
600.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NamePerlapinehydrochloride(watersoluble)
- ShortdescriptionNovel,potentandselectivehM3DqDREADDreceptoragoNIST.Watersoluble.
- BIOLOGicaldescription
Perlapinehydrochlorideisawatersolubleversionofperlapinewhichisanovel,potentandselective,non-CNO(ClozapineNOxide)hM3DqDREADDreceptoragonist(EC50=2.8nM).PerlapinealsoactivatestheinhibitoryhM2DiandhM4DiGi-DREADDs.
Perlapineshows>10,000-foldselectivityforhM3DqoverhM3muscarinicreceptor.Unlike CNO,perlapineisespeciallysuitedfortranslationalstudies.Perlapinealsoactsasasleepinducing,hypnoticagent.
ClozapineN-oxide(CNO) (watersoluble),Compound21,SalvinorinB(SalB)andperlapinefreebase arealsoavailable. - AlternativenamesNSC291840hydrochloride
- BiologicalactionActivator
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepinedihydrochloride
- MolecularWeight360.3
- Chemicalstructure
- MolecularFormulaC19H21N3.2HCl
- SMILESCN1CCN(CC1)C2=NC3=CC=CC=C3CC4=CC=CC=C42.Cl.Cl
- SourceSynthetic
- AppearanceWhitesolid
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinwater(100mM)
- HandlingHydroscopicsolid,contactwithairmaycausematerialtobecomesticky.Productperformanceshouldnotbeaffectedbutwerecommendstoringthematerialinasealedjar.
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse
ReferencesforPerlapinehydrochloride(watersoluble)
Thefirststructure-activityrelationshipstudiesfordesignerreceptorsexclusivelyactivatedbydesignerdrugs.
Chenetal(2015)ACSChemNeurosci6(3):476-84PubMedID:255878886-(4-Methyl-1-piperazinyl)morphanthridine(Perlapine),anewtricycliccompoundwithsedativeandsleep-promotingproperties.Apharmacologicalstudy.
Stilleetal(1973)Psychopharmacologia24(4):325-37PubMedID:4695567DREADDsforNeuroscientists.
RothBl(2016)Neuron89(4):683-94PubMedID:26889809
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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