Hello Bio/PEP 005/HB0482/2.5mg
商品编号：
HB0482-2.5mg
品牌：
hellobio
市场价：
¥4797.00
美元价：
3690.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
-
NamePEP 005
-
Short descriptionBroad spectrum PKC agonist
-
Biological descriptionBroad spectrum protein kinase C (PKC) agonist. Also inhibits AKT pathway. Displays pro-apoptotic, anti-proliferative, pro-inflammatory and anti-cancer properties.
-
Alternative namesIngenol 3-angelate
-
Biological actionAgonist
-
Purity>98%
-
Our products in actionSubmit Your Citation Now
Properties
-
Chemical name(2Z)-2-Methyl-2-butenoic acid (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2 ,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydro xymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-metha nocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester
-
Molecular Weight430.53
-
Chemical structure
![PEP 005 [75567-37-2]](images/hellobio/201710/hb0482.png "PEP 005 [75567-37-2]")
-
Molecular FormulaC25H34O6
-
CAS Number75567-37-2
Storing and Using Your Product
-
Storage instructions-20°C
-
Solubility overviewsoluble in DMSO (2mM)
-
ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for PEP 005
Kinetics of ERK1/2 activation determine sensitivity of acute myeloid leukaemia cells to the induction of apoptosis by the novel small molecule ingenol 3-angelate (PEP005).
Hampson P et al (2010) Apoptosis 15(8) : 946-55.PubMedID: 20467815The protein kinase C agonist PEP005 (ingenol 3-angelate) in the treatment of human cancer: a balance between efficacy and toxicity.
Ersvaer E et al (2010) Toxins (Basel) 2(1) : 174-94.PubMedID: 22069553Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells.
Serova M et al (2008) Mol Cancer Ther 7(4) : 915-22.PubMedID: 18413805Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells.
Benhadji KA et al (2008) Br J Cancer 99(11) : 1808-15.PubMedID: 19034280
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
