Hello Bio/PAC 1/HB1291/50mg
商品编号：
HB1291-50mg
品牌：
hellobio
市场价：
¥5499.00
美元价：
4230.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NamePAC1
- ShortdescriptionProcaspase-activatingcompound
- BIOLOGicaldescriptionProcaspase-activatingcompound.Chelatesinhibitoryzincionsandactivatesprocaspase-3tocaspase-3(EC50=0.22µM).Activatesprocaspase-7(EC50=4.5µM).NoeffectatlowpHasprocaspaseautoactivates.CausesEro1α-dependentcalciumleakagefromtheendoplasmicreticulumtomitochondria.Showsapoptoticandanti-canceractions.
- BiologicalactionActivator
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-(Phenylmethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
- MolecularWeight392.5
- MolecularFormulaC23H28N4O2
- CASNumber315183-21-2
StoringandUsingYourProduct
- Storageinstructions+4°C
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforPAC1
Procaspase-3activationasananti-cancerstrategy:structure-activityrelationshipofprocaspase-activatingcompound1(PAC-1)anditscellularco-localizationwithcaspase-3.
PetersonQPetal(2009)JMedChem52(18):5721-31.PubMedID:19708658Small-moleculeactivationofprocaspase-3tocaspase-3asapersonalizedanticancerstrategy.
PuttKSetal(2006)NatChemBiol2(10):543-50.PubMedID:16936720ERO1α-dependentendoplasmicreticulum-mitochondrialcalciumfluxcontributestoERstressandmitochondrialpermeABIlizationbyprocaspase-activatingcompound-1(PAC-1).
SeerviMetal(2013)CellDeathDis4:e968.PubMedID:24357799
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
