Hello Bio/NS 309/HB1049/10mg
商品编号：
HB1049-10mg
品牌：
hellobio
市场价：
¥819.00
美元价：
630.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameNS309
- ShortdescriptionPotent,selectiveKCa3.1/KCa2channelsubfamilyactivator
- BIOLOGicaldescriptionPotentandselectiveKCa3.1channelandKCa2channelsubfamilyactivator(EC50=0.3µMforKCa2.3).ExhibitslittleornoactivityatKCa1.1channels.Displays>1000foldhigherpotencythan1-EBIO.
- BiologicalactionActivator
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname6,7-Dichloro-1H-indole-2,3-dione3-oxime
- MolecularWeight231.04
- Chemicalstructure
![NS 309 [18711-16-5]](images/hellobio/201710/hb1049.png "NS 309 [18711-16-5]")
- MolecularFormulaC8H4Cl2N2O2
- CASNumber18711-16-5
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforNS309
ActivationofhumanIKandSKCa2+-activatedK+channelsbyNS309(6,7-dichloro-1H-indole-2,3-dione3-oxime).
StrøbaekDetal(2004)BiochimBiophysActa1665(1-2):1-5.PubMedID:15471565NS309decreasesratdetrusorsmoothmusclemembranepotentialandphasiccontractionsbyactivatingSK3channels.
ParajuliSPetal(2013)BrJPharmacol168(7):1611-25.PubMedID:23145946SelectivepositivemodulationoftheSK3andSK2subtypesofsmallconductanceCa2+-activatedK+channels.
HougaardCetal(2007)BrJPharmacol151(5):655-65.PubMedID:17486140
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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