你好Bio/NS 1643/HB1066/50mg
商品编号：
HB1066-50mg
品牌：
hellobio
市场价：
¥5089.50
美元价：
3915.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameNS1643
- ShortdescriptionKv11.1channelactivator
- BIOLOGicaldescriptionKv11.1channelactivator(EC50=10.5µM).AlsoactivatesKv11.2channelsviadifferentmechanismandKv11.3channels.AdiphenylureaderivativethatirreversIBLyinhibitscellproliferation.
- BiologicalactionActivator
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN,N"-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
- MolecularWeight380.24
- Chemicalstructure
![NS 1643 [448895-37-2]](images/hellobio/201710/hb1066.png "NS 1643 [448895-37-2]")
- MolecularFormulaC15H10F6N2O3
- CASNumber448895-37-2
StoringandUsingYourProduct
- Storageinstructions+4°C
- Solubilityoverviewsolubleinethanol(100mM)orDMSO(25mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforNS1643
Activationofhumanether-a-go-go-relatedgenepotassiumchannelsbythediphenylurea1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea(NS1643).
HansenRSetal(2006)MolPharmacol69(1):266-77.PubMedID:16219910ActivationofERG2potassiumchannelsbythediphenylureaNS1643.
ElmedybPetal(2007)Neuropharmacology53(2):283-94.PubMedID:17610913Potassiumchannelactivationinhibitsproliferationofbreastcancercellsbyactivatingasenescenceprogram.
LansuKetal(2013)CellDeathDis4:e652.PubMedID:23744352EffectsofthesmallmoleculeHERGactivatorNS1643onKv11.3channels.
BiletAetal(2012)PLoSOne7(11):e50886.PubMedID:23226420
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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