Hello Bio/NS 1619/HB1048/25mg
商品编号：
HB1048-5mg
品牌：
hellobio
市场价：
¥1326.00
美元价：
1020.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
Properties
- Chemicalname1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
- MolecularWeight362.23
- Chemicalstructure
![NS 1619 [153587-01-0]](images/hellobio/201710/hb1048.png "NS 1619 [153587-01-0]")
- MolecularFormulaC15H8F6N2O2
- CASNumber153587-01-0
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforNS1619
Large-conductanceK+channelopenersNS1619andNS004asinhibitorsofmitochondrialfunctioningliomacells.
DebskaGetal(2003)BiochemPharmacol65(11):1827-34.PubMedID:12781334RoleofROS/RhoA/PI3K/PKBsignalinginNS1619-mediatedblood-tumorbarrierpermeabilityincrease.
GuYTetal(2012)JMolNeurosci48(1):302-12.PubMedID:225814385-(4"-Substituted-2"-nitroanilino)-1,2,3-triazolesasnewpotentialpotassiumchannelactivators.I.
BiagiGetal(2000)EurJMedChem35(7-8):715-20.PubMedID:10960187LargeconductanceCa2+-activatedK+channelactivationwithNS1619decreasesmyogenicandneurogeniccontractionsofratdetrusorsmoothmuscle.
SoderRPetal(2011)EurJPharmacol670(1):252-9.PubMedID:21914438
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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