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当前位置: 首页 > 产品中心 > acid_base_buffer_solution > Hello Bio/NS 1619/HB1048/5mg
商品详细Hello Bio/NS 1619/HB1048/5mg
Hello Bio/NS 1619/HB1048/5mg
Hello Bio/NS 1619/HB1048/5mg
商品编号: HB1048-5mg
品牌: hellobio
市场价: ¥1326.00
美元价: 1020.00
产地: 美国(厂家直采)
公司:
产品分类: 酸碱缓冲液
公司分类: acid_base_buffer_solution
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Productoverview

  • Name
    NS1619
  • Shortdescription
    Potent,selectiveKCa1.1channelactivator
  • BIOLOGicaldescription
    PotentandselectiveKCa1.1channelactivator(EC50=3.6µM).SelectivelyincreasesthebloodbrainbarrierpermeABIlity.Displaysvasorelaxantproperties
  • Biologicalaction
    Activator
  • Purity
    >98%
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • Chemicalname
    1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
  • MolecularWeight
    362.23
  • Chemicalstructure
    NS 1619 [153587-01-0]
  • MolecularFormula
    C15H8F6N2O2
  • CASNumber
    153587-01-0

StoringandUsingYourProduct

  • Storageinstructions
    +4°C
  • Solubilityoverview
    solubleinDMSO(100mM)orethanol(100mM)
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforNS1619

  • Large-conductanceK+channelopenersNS1619andNS004asinhibitorsofmitochondrialfunctioningliomacells.

    DebskaGetal(2003)BiochemPharmacol65(11):1827-34.
    PubMedID:12781334
  • RoleofROS/RhoA/PI3K/PKBsignalinginNS1619-mediatedblood-tumorbarrierpermeabilityincrease.

    GuYTetal(2012)JMolNeurosci48(1):302-12.
    PubMedID:22581438
  • 5-(4"-Substituted-2"-nitroanilino)-1,2,3-triazolesasnewpotentialpotassiumchannelactivators.I.

    BiagiGetal(2000)EurJMedChem35(7-8):715-20.
    PubMedID:10960187
  • LargeconductanceCa2+-activatedK+channelactivationwithNS1619decreasesmyogenicandneurogeniccontractionsofratdetrusorsmoothmuscle.

    SoderRPetal(2011)EurJPharmacol670(1):252-9.
    PubMedID:21914438
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor,  NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632,  SB 431542 DAPT.