Hello Bio/NMDA/HB0454/50mg
商品编号:
HB0454-50mg
品牌:
hellobio
市场价:
¥741.00
美元价:
570.00
产品分类:
酸碱缓冲液
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Productoverview
Images
Properties
- ChemicalnameN-Methyl-D-asparticacid
- MolecularWeight147.13
- Chemicalstructure
- MolecularFormulaC5H9NO4
- CASNumber6384-92-5
- PubChemidentifier22880
- SMILESCN[C@H](CC(=O)O)C(=O)O
- InChiInChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
- InChiKeyHOKKHZGPKSLGJE-GSVOUGTGSA-N
- MDLnumberMFCD00004226
Applications
- Applicationnotes
TheprototypicNMDAreceptoragonistNMDAiseffectiveatarangeofconcentrationsandtypicallyusedat100μM.NMDAfromHelloBioinducesinwarddepolarisingwhole-cellcurrentsincorticalneuronsat10μMwithprominentcurrentsat50μM.TheactionsofNDMAwerefullyblockedbyD-AP5(NMDARantagonist)at100μM(seeFig1above).
#Protocol1:NMDAmediatedwhole-cellcurrents
- WholecellvoltageclamprecordingswereobtainedfromlayerVneuronsofthemouseprelimbiccortexbrainslice.
- Neuronswereheldat-70mVandcontinuouslyperfusedwithaCSFinthepresenceofAMPAandGABAreceptorantagonistsCNQX(10μM)andBicuculline(100μM)respectivelyandTetrodotoxin(1μM)toreducenetworkactivity.
- NMDAcurrentswereevokedbyapplyingNMDAdirectlytotherecordingchamberduringcontinuousperfusion.
•TotesttheselectivityofNMDAtoNMDAreceptorstheexperimentwasrepeatedwithinthesameneuroninthepresenceoftheNMDAreceptorantagonistD-AP5(100μM).UndertheseconditionsNMDAfailedtoinduceadepolarisingcurrent.
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinwater(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforNMDA
N-methyl-D-asparticacid(NMDA)inthenervoussystemoftheamphioxusBranchiostomalanceolatum.
D"AnielloSetal(2007)BMCNeurosci8:109PubMedID:18096065RegulationofN-methyl-D-asparticacid(NMDA)receptorsbymetabotropicglutamatereceptor7.
GuZetal(2012)JBiolChem287(13):10265-75.PubMedID:22287544OccurrenceofD-asparticacidandN-methyl-D-asparticacidinratneuroendocrinetissuesandtheirroleinthemodulationofluteinizinghormoneandgrowthhormonerelease.
D"AnielloAetal(2000)FASEBJ14(5):699-714.PubMedID:10744627
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业,总部位于英国布里斯托尔,在美国普林斯顿设有分公司,主旨在于提供质优价廉的生命科学研究工具,主要产品线为小分子化合物,如激动剂、拮抗剂、抑制剂等,部分产品价格甚至低至其他供应商的50%。热销产品线:酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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