Hello Bio/ML 213/HB1064/25mg
商品编号：
HB1064-25mg
品牌：
hellobio
市场价：
¥2574.00
美元价：
1980.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameML213
- ShortdescriptionSelectiveKv7.2/Kv7.4channelactivator
- BIOLOGicaldescriptionSelectiveKv7.2andKv7.4channelactivator(EC50valuesare230and510nMrespectively).Exhibits>80-foldselectivityforKv7.2andKv7.4channelsoverotherK+channels.Displaysvasorelaxantproperties.
- BiologicalactionActivator
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide
- MolecularWeight257.37
- Chemicalstructure
![ML 213 [489402-47-3]](images/hellobio/201710/hb1064.png "ML 213 [489402-47-3]")
- MolecularFormulaC17H23NO
- CASNumber489402-47-3
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(50mM)orethanol(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforML213
Discovery,Synthesis,andStructureActivityRelationshipofaSeriesofN-Aryl-bicyclo[2.2.1]heptane-2-carboxamides:CharacterizationofML213asaNovelKCNQ2andKCNQ4PotassiumChannelOpener.
YuHetal(2011)ACSChemNeurosci2(10):572-577.PubMedID:22125664VasorelaxanteffectsofnovelKv7.4channelenhancersML213andNS15370.
JeppsTAetal(2014)BrJPharmacol171(19):4413-24.PubMedID:24909207DifferentialactivationofvascularsmoothmuscleKv7.4,Kv7.5,andKv7.4/7.5channelsbyML213andICA-069673.
BrueggemannLIetal(2014)MolPharmacol86(3):330-41.PubMedID:24944189
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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