你好Bio/Mepyramine马来酸盐/HB2622/100mg
商品编号：
HB2622-100mg
品牌：
hellobio
市场价：
¥799.50
美元价：
615.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameMepyraminemaleate
- ShortdescriptionSelectiveH1receptorinverseagoNIST
- BIOLOGicaldescriptionSelectiveH1receptorinverseagonist.SelectiveforH1overH2,H3andH4receptors(Kivaluesare0.4nM,5.2,>10and>10µMrespectively).AlsoapotentKCNQ/Mpotassiumchannelblocker.Showsanti-allergicandneuroexcitatoryactions.Blood-brainbarrierpermeable.
- AlternativenamesPyrilaminemaleate
- BiologicalactionAgonist
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridinemaleate
- MolecularWeight401.46
- Chemicalstructure
- MolecularFormulaC17H23N3O.C4H4O4
- CASNumber59-33-6
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforMepyraminemaleate
Histamineanditsreceptors.
ParsonsMEetal(2006)BrJPharmacol147Suppl1:S127-35.PubMedID:16402096TransportmechanismofanH1-antagonistattheblood-brainbarrier:transportmechanismofmepyramineusingthecarotidinjectiontechnique.
YamazakiMetal(1994)BiolPharmBull17(5):676-9.PubMedID:7920432AntihistaminemepyraminedirectlyinhibitsKCNQ/Mchannelanddepolarizesratsuperiorcervicalganglionneurons.
LiuBetal(2008)Neuropharmacology54(4):629-39.PubMedID:18222495
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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