你好Bio/Loperamide盐酸盐/HB0385/1g
市场价：
¥741.00
美元价：
570.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameLoperamidehydrochloride
- ShortdescriptionPotent,selectiveµ-opioidreceptoragoNIST
- BIOLOGicaldescriptionPotentandselectiveµ-opioidreceptoragonist(Kivaluesare3,48and1156nMforµ,δandκ).Blocksvoltage-activatedcalciumchannelsandalsoNMDAreceptorCa2+influxathigherconcentrations.Showsantidiarrhealandantihyperalgesicactions.
- BiologicalactionAgonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidiNEButanamidehydrochloride
- MolecularWeight513.51
- Chemicalstructure
![Loperamide hydrochloride [34552-83-5]](images/hellobio/201710/hb0385.png "Loperamide hydrochloride [34552-83-5]")
- MolecularFormulaC29H33ClN2O2.HCl
- CASNumber34552-83-5
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- Solubilityoverviewsolubleinethanol(50mM)orDMSO(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforLoperamidehydrochloride
Loperamide(ADL2-1294),anopioidantihyperalgesicagentwithperipheralselectivity.
DeHaven-HudkinsDLetal(1999)JPharmacolExpTher289(1):494-502.PubMedID:10087042Loperamideblockshigh-voltage-activatedcalciumchannelsandN-methyl-D-aspartate-evokedresponsesinratandmouseculturedhippocampalpyramidalneurons.
ChurchJetal(1994)MolPharmacol45(4):747-57.PubMedID:8183255Maitotoxin-elicitedcalciuminfluxinculturedcells.Effectofcalcium-channelblockers.
DalyJWetal(1995)BiochemPharmacol50(8):1187-97.PubMedID:7488233
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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