Product overview

• Name
  Kainic acid
• Short description
  Prototypic, selective kainate receptor agonist. Potent excitant and neurotoxin.
• Biological description

  Prototypic, selective kainate receptor (KAR) agonist. Analog of L-Glutamate.

  
  Potent excitant and neurotoxin (shows ~30-fold more neurotoxic potency than L-Glutamate).

  Induces various changes in vivo including recurrent seizures, behavioural changes, oxidative stress, glial activation and selective neuronal death.

  
  Kainic acid exerts its neuroexcitatory action by binding to glutamate receptors to cause Ca²⁺ influx and triggering subsequent excitotoxic neuronal death pathway cascades.

  Kainic acid is widely used to model various neurodegenerative diseases and epilepsy.

• Biological action
  Agonist
• Purity
  >98%
• Customer comments

  We tested the Kainic acid and we are very happy with it. Hello Bio Kainic acid was used at 25 mg/kg i.p. and successfully induced status epilepticus. Verified customer, CNRS, France

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Properties

• Chemical name
  (2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
• Molecular Weight
  213.23
• Chemical structure
  
• Molecular Formula
  C₁₀H₁₅NO₄
• CAS Number
  487-79-6
• PubChem identifier
  10255
• SMILES
  CC(=C)[C@H]1CNC([C@H]1CC(=O)O)C(=O)O
• Source
  Extracted from diginea simplex
• InChi
  InChI=1S/C10H15NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1
• InChiKey
  VLSMHEGGTFMBBZ-OOZYFLPDSA-N
• MDL number
  MFCD00150833
• Appearance
  White solid

Applications

• Application notes

  The kainate receptor (KAR) agonist kainic acid induces neuronal oscillations in the gamma frequency band (35-100Hz). KAR activation leads to synchronous activity of excitatory and inhibitory network firing. Kainic acid is commonly used at concentrations of 400-600 nM to induce oscillations in acute brain slices. At a concentration of 550 nM, kainic acid from Hello Bio induces a strong gamma frequency neuronal oscillation (approx. 35Hz) within the CA3 region of the rat hippocampus (see Fig 1 above). Oscillations were abolished following kainic acid washout.

   

  #Protocol 1: Oscillations assay

  • Acute rat hippocampal slices were placed in an interface chamber and held at 30°C with a glass recording electrode placed in the CA3 region of the hippocampus.
  • Control basal activity was recorded for 1 hr in the presence of aCSF before continuous perfusion of aCSF containing kainic acid at 550nM to induce oscillations.
  • Oscillation activity was recorded once oscillations had stabilised (~2-3 hours). 
  • Kainic acid was then washed out and replaced with control aCSF. 
  • Data were analysed to create a power spectrum of the oscillation.

   

Storing and Using Your Product

• Storage instructions
  Room temperature
• Solubility overview
  Soluble in water (25mM, gentle warming)
• Important
  This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.