你好生物/（-）-吲哚内酰胺V/HB0002/1mg
商品编号：
HB0002-1mg
品牌：
hellobio
市场价：
¥2457.00
美元价：
1890.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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Name(-)-Indolactam V
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Short descriptionSynthetic PKC activator
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Biological descriptionSynthetic protein kinase C (PKC) inhibitor. Also induces embryonic stem cell differentiation. Displays tumor promoting properties with mitogenic and comitogenic activating effects.
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Biological actionActivator
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Purity>99%
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Properties
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Chemical name(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
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Molecular Weight301.38
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Chemical structure
![(-)-Indolactam V [90365-57-4]](images/hellobio/201710/hb0002.png "(-)-Indolactam V [90365-57-4]")
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Molecular FormulaC17H23N3O2
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CAS Number90365-57-4
Storing and Using Your Product
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Storage instructions-20°C (desiccate)
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Solubility overviewsoluble in DMSO (10mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for (-)-Indolactam V
Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V.
Nakagawa Y et al (1997) Biosci Biotechnol Biochem 61(8) : 1415-7.PubMedID: 9301127(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells.
Heikkilä J et al (1989) Biochem Biophys Res Commun 162(3) : 1207-13.PubMedID: 2764930(-)-Indolactam V-induced mitogenesis in human fetal/neonatal and adult T cells: lower response of neonatal cells and possible regulatory role of monocytes in protein kinase C-mediated pathways.
Papadogiannakis N (1995) Cell Immunol 162(2) : 288-94.PubMedID: 7743557A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
Chen S et al (2009) Nat Chem Biol 5(4) : 258-65.PubMedID: 19287398
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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