Hello Bio/Icilin/HB1153/50mg
商品编号：
HB1153-50mg
品牌：
hellobio
市场价：
¥5050.50
美元价：
3885.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameIcilin
- ShortdescriptionPotentTRPM8channelagoNIST
- BIOLOGicaldescriptionPotentTRPM8channelagonist.Approx200-foldmorepotentthanmethanol(EC50valuesof0.36and66.7µMforicilinandmethanolrespectively).CoolingagentthatalsoactivatesTRPA1coldchannel.AlsoTRPV3channelinhibitor(IC50=0.5µM).
- BiologicalactionAgonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one
- MolecularWeight311.3
- Chemicalstructure
![Icilin [36945-98-9]](images/hellobio/201710/hb1153.png "Icilin [36945-98-9]")
- MolecularFormulaC16H13N3O4
- CASNumber36945-98-9
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforIcilin
Characterizationofthemousecold-mentholreceptorTRPM8andvanilloidreceptortype-1VR1usingafluorometricimagingplatereader(FLIPR)assay.
BehrendtHJetal(2004)BrJPharmacol141(4):737-45.PubMedID:14757700ANKTM1,aTRP-likechannelexpressedinnociceptiveneurons,isactivatedbycoldtemperatures.
StoryGMetal(2003)Cell112(6):819-29.PubMedID:12654248Supercoolingagenticilinblocksawarmth-sensingionchannelTRPV3.
SherkheliMAetal(2012)ScientificWorldJournal2012:982725PubMedID:22548000IdentificationofacoldreceptorrevealsageneralroleforTRPchannelsinThermosensation.
McKemyDDetal(2002)Nature416(6876):52-8.PubMedID:11882888
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
联络我们
