Hello Bio/Ibotenic acid/HB0330/5mg
商品编号：
HB0330-5mg
品牌：
hellobio
市场价：
¥2691.00
美元价：
2070.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameIbotenic acid
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Short descriptionNon-selective NMDA / mGlu receptor agonist
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Biological descriptionNon-selective NMDA and mGlu receptor agonist (EC50 values are 17, 43, 110, >1000 and >1000 μM for mGlu5a, mGlu1a, mGlu2, mGlu4a and mGlu6 receptors respectively). Shows excitotoxic actions. Used for cognitive dysfunction models for neurodegenerative disease research.
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Biological actionAgonist
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical nameα-Amino-(3-hydroxy-5-isoxazolyl)acetic acid
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Molecular Weight158.11
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Chemical structure
![Ibotenic acid [2552-55-8]](images/hellobio/201710/hb0330.png "Ibotenic acid [2552-55-8]")
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Molecular FormulaC5H6N2O4
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CAS Number2552-55-8
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PubChem identifier1233
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SMILESC1=C(ONC1=O)C(C(=O)O)N
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InChiInChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
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InChiKeyIRJCBFDCFXCWGO-UHFFFAOYSA-N
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MDL numberMFCD00069294
Storing and Using Your Product
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Storage instructions-20°C (desiccate)
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Solubility overviewSoluble in water (10mM) and in 0.1M NaOH (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Ibotenic acid
Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.
Hermit MB et al (2004) Eur J Pharmacol 486(3) : 241-50.PubMedID: 14985045Neurochemical and behavioral effects of the intrahippocampal co-injection of beta-amyloid protein1-40 and ibotenic acid in rats.
Li Y et al (2005) Life Sci 76(11) : 1189-97.PubMedID: 15642590Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors.
Bräuner-Osborne H et al (1998) Eur J Pharmacol 350(2-3) : 311-6.PubMedID: 9696422Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitants.
Perkins MN et al (1982) Neurosci Lett 32(1) : 65-8.PubMedID: 6755315
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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