你好Bio/Ibotenic acid/HB0330/1mg
商品编号：
HB0330-1mg
品牌：
hellobio
市场价：
¥780.00
美元价：
600.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameIbotenicacid
- ShortdescriptionNon-selectiveNMDA/mGlureceptoragoNIST
- BIOLOGicaldescriptionNon-selectiveNMDAandmGlureceptoragonist(EC50valuesare17,43,110,>1000and>1000μMformGlu5a,mGlu1a,mGlu2,mGlu4aandmGlu6receptorsrespectively).Showsexcitotoxicactions.Usedforcognitivedysfunctionmodelsforneurodegenerativediseaseresearch.
- BiologicalactionAgonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalnameα-Amino-(3-hydroxy-5-isoxazolyl)aceticacid
- MolecularWeight158.11
- Chemicalstructure
![Ibotenic acid [2552-55-8]](images/hellobio/201710/hb0330.png "Ibotenic acid [2552-55-8]")
- MolecularFormulaC5H6N2O4
- CASNumber2552-55-8
- PubChemidentifier1233
- SMILESC1=C(ONC1=O)C(C(=O)O)N
- InChiInChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
- InChiKeyIRJCBFDCFXCWGO-UHFFFAOYSA-N
- MDLnumberMFCD00069294
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewSolubleinwater(10mM)andin0.1MNaOH(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforIbotenicacid
Ibotenicacidandthioibotenicacid:aremarkabledifferenceinactivityatgroupIIImetabotropicglutamatereceptors.
HermitMBetal(2004)EurJPharmacol486(3):241-50.PubMedID:14985045NeuRochemicalandbehavioraleffectsoftheintrahippocampalco-injectionofbeta-amyloidprotein1-40andibotenicacidinrats.
LiYetal(2005)LifeSci76(11):1189-97.PubMedID:15642590Molecularpharmacologyofhomologuesofibotenicacidatclonedmetabotropicglutamicacidreceptors.
Bräuner-OsborneHetal(1998)EurJPharmacol350(2-3):311-6.PubMedID:9696422Isomersof2-amino-7-phosphonoheptanoicacidasantagonistsofneuronalexcitants.
PerkinsMNetal(1982)NeurosciLett32(1):65-8.PubMedID:6755315
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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