你好Bio/Ganaxolone/HB0938/50mg
商品编号：
HB0938-50mg
品牌：
hellobio
市场价：
¥5538.00
美元价：
4260.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameGanaxolone
- ShortdescriptionPotentGABAAreceptorpositiveallostericmodulator
- BIOLOGicaldescriptionPotentGABAAreceptorpositiveallostericmodulator(EC50valuesare94,122and213nMforα2β1γ2L,α3β1γ2Landα1β1γ2Lreceptorsrespectively).Neuroactivesteroid;enhances[3H]flunitrazepambinding(EC50=125nM).DecreasesethanolconsumptioninaddictionmodelsandshowsactionsagainstMultipleSclerosis.Showssedative,anxiolyticandanticonvulsanteffects.Blood-brainbarrierpermeable.
- BiologicalactionPAM
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one
- MolecularWeight332.53
- Chemicalstructure
![Ganaxolone [38398-32-2]](images/hellobio/201710/hb0938.png "Ganaxolone [38398-32-2]")
- MolecularFormulaC22H36O2
- CASNumber38398-32-2
StoringandUsingYourProduct
- Storageinstructions+4°C
- SolubilityoverviewsolubleinDMSO(100mM)orethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforGanaxolone
Characterizationoftheanticonvulsantpropertiesofganaxolone(CCD1042;3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one),aselective,high-affinity,steroidmodulatorofthegamma-aminobutyricacid(A)receptor.
CarterRBetal(1997)JPharmacolExpTher280(3):1284-95.PubMedID:9067315EffectofganaxoloneandTHIPonoperantandlimited-accessethanolself-admiNISTration.
RamakerMJetal(2012)Neuropharmacology63(4):555-64.PubMedID:22613838GABAtransportandneuroinflammationarecoupledinmultiplesclerosis:regulationoftheGABAtransporter-2byganaxolone.
PaulAMetal(2014)Neuroscience273:24-38.PubMedID:24814730
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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