你好Bio/丙酸氟替卡松/HB1091/25mg
商品编号：
HB1091-25mg
品牌：
hellobio
市场价：
¥4543.50
美元价：
3495.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameFluticasone propionate
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Short descriptionSelective glucocorticoid receptor agonist
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Biological descriptionSelective glucocorticoid receptor agonist (Kd = 0.5 nM). Reduces expression of mast cells, suppresses mast cell degranulation, enhances eosinophil apoptosis and inhibits T cell proliferation. Potentiates Kv1 channel current (EC50 = 37 nM). Shows anti-inflammatory and anti-allergy actions.
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Biological actionAgonist
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester
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Molecular Weight500.57
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Chemical structure
![Fluticasone propionate [80474-14-2]](images/hellobio/201710/hb1091.png "Fluticasone propionate [80474-14-2]")
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Molecular FormulaC25H31F3O5S
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CAS Number80474-14-2
Storing and Using Your Product
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Storage instructionsroom temperature
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Solubility overviewsoluble in DMSO (50mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Fluticasone propionate
The anti-inflammatory profile of fluticasone propionate.
Johnson M (1995) Allergy 50(23 Suppl) : 11-4.PubMedID: 7604948Basic research on virus-induced asthma exacerbation: inhibition of inflammatory chemokine expression by fluticasone propionate.
Matsukura S et al (2013) Int Arch Allergy Immunol 161 Suppl 2 : 84-92.PubMedID: 23711858Potentiation of the Kv1 family K(+) channel by cortisone analogues.
Pan Y et al (2012) ACS Chem Biol 7(10) : 1641-6.PubMedID: 22803826Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone.
Zhang X et al (2000) Eur J Pharmacol 406(3) : 325-32.PubMedID: 11040338
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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