Hello Bio/FGIN-1-27/HB0913/25mg
商品编号：
HB0913-25mg
品牌：
hellobio
市场价：
¥1423.50
美元价：
1095.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameFGIN-1-27
- ShortdescriptionPotent,selectiveMDRreceptoragoNIST
- BIOLOGicaldescriptionPotentandselectivemitochondrialdiazepambindinginhibitorreceptor(MDR)agonist,alsoknownasperipheralbenzodiazepinereceptors.IncreaseLeydigcellsteroidandneurosteroidproduction.IndirectlymodulatesGABAAreceptorsbyincreasingneurosteroids.Showsanti-convulsantactions.Blood-brainbarrierpermeable.
- BiologicalactionAgonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- ChemicalnameN,N-Dihexyl-2-(4-fluorophenyl)indole-3-acetamide
- MolecularWeight436.61
- Chemicalstructure
![FGIN-1-27 [142720-24-9]](images/hellobio/201710/hb0913.png "FGIN-1-27 [142720-24-9]")
- MolecularFormulaC28H37FN2O
- CASNumber142720-24-9
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforFGIN-1-27
2-Aryl-3-indoleacetamides(FGIN-1):anewclassofpotentandspecificligandsforthemitochondrialDBIreceptor(MDR).
RomeoEetal(1992)JPharmacolExpTher262(3):971-8.PubMedID:1326631Drugligand-inducedactivationoftranslocatorprotein(TSPO)stimulatessteroidproductionbyagedbrownNorwayratLeydigcells.
ChungJYetal(2013)Endocrinology154(6):2156-65.PubMedID:23525219Developmentofligandsfortheperipheralbenzodiazepinereceptor.
JamesMLetal(2006)CurrMedChem13(17):1991-2001.PubMedID:16842193Stimulationofbrainpregnenolonesynthesisbymitochondrialdiazepambindinginhibitorreceptorligandsinvivo.
KorneyevAetal(1993)JNeuRochem61(4):1515-24.PubMedID:8397297
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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