Hello Bio/Etomidate/HB0937/50mg
商品编号：
HB0937-50mg
品牌：
hellobio
市场价：
¥3685.50
美元价：
2835.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameEtomidate
- ShortdescriptionPotentGABAAreceptorpositiveallostericmodulator
- BIOLOGicaldescriptionPotentGABAAreceptorpositiveallostericmodulator.Selectiveforβ2andβ3subunits(EC50valuesare0.6,0.7and7.4µMforα6β2γ2,α6β3γ2andα6β1γ2GABAAreceptorsubtypesrespectively).Showsshortactinghypnoticactions.Blood-brainbarrierpermeable.
- BiologicalactionPAM
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(R)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylicacidethylester
- MolecularWeight244.29
- Chemicalstructure
![Etomidate [33125-97-2]](images/hellobio/201710/hb0937.png "Etomidate [33125-97-2]")
- MolecularFormulaC14H16N2O2
- CASNumber33125-97-2
- PubChemidentifier36339
- SMILESCCOC(=O)C1=CN=CN1C(C)C2=CC=CC=C2
- InChiInChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3
- InChiKeyNPUKDXXFDDZOKR-UHFFFAOYSA-N
- MDLnumberMFCD00869295
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinethanol(100mM)andin1MHCl(50mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforEtomidate
Distinctactionsofetomidateandpropofolatbeta3-containinggamma-aminobutyricacidtypeAreceptors.
DrexlerBetal(2009)Neuropharmacology57(4):446-55.PubMedID:19555700Etomidateandothernon-barbiturates.
VanlersbergheCetal(2008)HandbExpPharmacol-182:267-82.PubMedID:18175096Theinteractionofthegeneralanestheticetomidatewiththegamma-aminobutyricacidtypeAreceptorisinfluencedbyasingleaminoacid.
BelelliDetal(1997)ProcNatlAcadSciUSA94(20):11031-6.PubMedID:9380754
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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