Hello Bio/17 β-Estradiol/HB2494/100mg
商品编号：
HB2494-100mg
品牌：
hellobio
市场价：
¥604.50
美元价：
465.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Name17β-EstrADIol
- ShortdescriptionEstrogenreceptor(ER)agoNIST
- BIOLOGicaldescriptionEstrogenreceptor(ER)agonist(Kivaluesare0.13and0.12nMatERαandERβrespectively).AlsoshowsactivityatGPR30receptors(Ki=6nM).Endogenoushormone.Showsneuroprotectiveandantioxidanteffects.
- AlternativenamesEstradiol|E2
- BiologicalactionAgonist
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
- MolecularWeight272.38
- Chemicalstructure
![17 β-Estradiol [50-28-2]](images/hellobio/201710/hb2494.png "17 β-Estradiol [50-28-2]")
- MolecularFormulaC18H24O2
- CASNumber50-28-2
- PubChemidentifier5757
- SMILESC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O
- InChiInChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
- InChiKeyVOXZDWNPVJITMN-ZBRFXRBCSA-N
- MDLnumberMFCD00003693
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(100mM)andinethanol(75mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesfor17β-Estradiol
17-betaestradiolprotectsneuronsfromoxidativestress-inducedcelldeathinvitro.
BehlCetal(1995)BiochemBiophysResCommun216(2):473-82.PubMedID:7488136IdentityofanestrogenmembranereceptorcoupledtoaGproteininhumanbreastcancercells.
ThomasPetal(2005)Endocrinology146(2):624-32.PubMedID:15539556Comparisonoftheligandbindingspecificityandtranscripttissuedistributionofestrogenreceptorsalphaandbeta.
KuiperGGetal(1997)Endocrinology138(3):863-70.PubMedID:9048584TheinsandoutsofGPR30:atransmembraneestrogenreceptor.
ProssnitzERetal(2008)JSteroidBiochemMolBiol109(3-5):350-3.PubMedID:18406603
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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