Hello Bio/1-EBIO/HB1045/
市场价：
¥585.00
美元价：
450.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- Name1-EBIO
- ShortdescriptionEpithelialKCachannelactivator.PromotesESCdifferentiationintocardiomyocytes.
- BIOLOGicaldescriptionEpithelialKCachannelactivator(K0.5=84µMforKCa3.1channels).Hyperpolarisesaorticvalveendothelialcellstothesameextentasacetylcholine.Alsopromotesembroyonicstemcell(ESC)differentiationintocardiomyocytes.Displaysvasodilationandanticonvulsantproperties.
- BiologicalactionActivator
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname1-Ethyl-2-benzimidazolinone
- MolecularWeight162.19
- Chemicalstructure
![1-EBIO [10045-45-1]](images/hellobio/201710/hb1045.png "1-EBIO [10045-45-1]")
- MolecularFormulaC9H10N2O
- CASNumber10045-45-1
- PubChemidentifier82320
- SMILESCCN1C2=CC=CC=C2NC1=O
- InChiInChI=1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12)
- InChiKeyCXUCKELNYMZTRT-UHFFFAOYSA-N
- MDLnumberMFCD00005715
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(100mM)andinethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
Referencesfor1-EBIO
1-Ethyl-2-benzimidazolinonestimulatesendothelialK(Ca)channelsandnitricoxideformationinratmesentericvessels.
AdeagboAS(1999)EurJPharmacol379(2-3):151-9.PubMedID:10497901Pharmacologicalactivationofclonedintermediate-andsmall-conductanceCa(2+)-activatedK(+)channels.
SymeCAetal(2000)AmJPhysiolCellPhysiol278(3):C570-81.PubMedID:10712246Invivocharacterisationofthesmall-conductanceKCa(SK)channelactivator1-ethyl-2-benzimidazolinone(1-EBIO)asapotentialanticonvulsant.
AndersonNJetal(2006)EurJPharmacol546(1-3):48-53.PubMedID:16925994ReducedhyperpolarizationinendothelialcellsofrabbitaorticvalvefollowingchronicnitroglycerineadmiNISTration.
KusamaNetal(2005)BrJPharmacol146(4):487-97.PubMedID:16056232
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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