你好Bio/1-EBIO/HB1045/10mg
商品编号：
HB1045-10mg
品牌：
hellobio
市场价：
¥565.50
美元价：
435.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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Name1-EBIO
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Short descriptionEpithelial KCa channel activator. Promotes ESC differentiation into cardiomyocytes.
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Biological descriptionEpithelial KCa channel activator (K0.5 = 84 µM for KCa3.1 channels). Hyperpolarises aortic valve endothelial cells to the same extent as acetylcholine. Also promotes embroyonic stem cell (ESC) differentiation into cardiomyocytes. Displays vasodilation and anticonvulsant properties.
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Biological actionActivator
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Purity>99%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name1-Ethyl-2-benzimidazolinone
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Molecular Weight162.19
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Chemical structure
![1-EBIO [10045-45-1]](images/hellobio/201710/hb1045.png "1-EBIO [10045-45-1]")
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Molecular FormulaC9H10N2O
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CAS Number10045-45-1
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PubChem identifier82320
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SMILESCCN1C2=CC=CC=C2NC1=O
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InChiInChI=1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12)
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InChiKeyCXUCKELNYMZTRT-UHFFFAOYSA-N
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MDL numberMFCD00005715
Storing and Using Your Product
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Storage instructionsRoom temperature
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Solubility overviewSoluble in DMSO (100mM) and in ethanol (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for 1-EBIO
1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels.
Adeagbo AS (1999) Eur J Pharmacol 379(2-3) : 151-9.PubMedID: 10497901Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels.
Syme CA et al (2000) Am J Physiol Cell Physiol 278(3) : C570-81.PubMedID: 10712246In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant.
Anderson NJ et al (2006) Eur J Pharmacol 546(1-3) : 48-53.PubMedID: 16925994Reduced hyperpolarization in endothelial cells of rabbit aortic valve following chronic nitroglycerine administration.
Kusama N et al (2005) Br J Pharmacol 146(4) : 487-97.PubMedID: 16056232
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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