你好Bio/DPN/HB2489/50mg
商品编号：
HB2489-50mg
品牌：
hellobio
市场价：
¥5187.00
美元价：
3990.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameDPN
- ShortdescriptionSelectiveERβestrogenreceptoragoNIST
- BIOLOGicaldescriptionSelectiveERβestrogenreceptoragonist(Kdvaluesare5and400nMatERβandERαrespectively).Shows70-foldselectivityatERβoverERα.Showsneuroprotectiveeffects.Activeinvivo.
- BiologicalactionAgonist
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname2,3-bis(4-Hydroxyphenyl)-propionitrile
- MolecularWeight239.27
- Chemicalstructure
![DPN [1428-67-7]](images/hellobio/201710/hb2489.png "DPN [1428-67-7]")
- MolecularFormulaC15H13NO2
- CASNumber1428-67-7
- PubChemidentifier102614
- SMILESC1=CC(=CC=C1CC(C#N)C2=CC=C(C=C2)O)O
- InChiInChI=1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
- InChiKeyGHZHWDWADLAOIQ-UHFFFAOYSA-N
- MDLnumberMFCD01695412
StoringandUsingYourProduct
- Storageinstructions-20°C(desiccate)
- SolubilityoverviewSolubleinDMSO(100mM)andinethanol(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforDPN
Estrogenreceptor-betapotency-selectiveligands:structure-activityrelationshipstudiesofdiarylpropionitrilesandtheiracetyleneandpolaranalogues.
MeyersMJetal(2001)JMedChem44(24):4230-51.PubMedID:11708925EstrogenreceptorsubtypesalphaandbetacontributetoneuroprotectionandincreasedBcl-2expressioninprimaryhippocampalneurons.
ZhaoLetal(2004)BrainRes1010(1-2):22-34.PubMedID:15126114ThepossIBLeroleofestrogenandselectiveestrogenreceptormodulatorsinaratmodelofParkinson"sdisease.
BarakaAMetal(2011)LifeSci88(19-20):879-85.PubMedID:21420980Pharmacokineticsoftheestrogenreceptorsubtype-selectiveligands,PPTandDPN:quantificationusingUPLC-ES/MS/MS.
SepehrEetal(2012)JPharmBiomedAnal71:119-26.PubMedID:22981216
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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