Hello Bio/Diazoxide/HB0244/1g
市场价：
¥1794.00
美元价：
1380.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Product overview
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NameDiazoxide
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Short descriptionSelective KIR6 activator
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Biological descriptionSelective KIR6 (ATP-sensitive K+) channel activator. Increases EPSCs to around 150% of control values. Shows cardioprotective actions during ischaemic injury by activating PKCε. Also shows neuroprotective and antihypertensive actions.
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Biological actionActivator
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Purity>98%
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Our products in actionSubmit Your Citation Now
Properties
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Chemical name7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine1,1-dioxide
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Molecular Weight230.67
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Chemical structure
![Diazoxide [364-98-7]](images/hellobio/201710/hb0244.png "Diazoxide [364-98-7]")
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Molecular FormulaC8H7ClN2O2S
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CAS Number364-98-7
Storing and Using Your Product
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Storage instructionsroom temperature
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Solubility overviewsoluble in DMSO (100mM)
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ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for Diazoxide
Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons.
Yamada KA et al (1992) J Physiol 458 : 409-23.PubMedID: 1302270Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury.
Kim MY et al (2006) Br J Pharmacol 149(8) : 1059-70.PubMedID: 17043673Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives.
Hansen JB (2006) Curr Med Chem 13(4) : 361-76.PubMedID: 16475928The neuroprotective effect of diazoxide is mediated by mitochondrial ATP-dependent potassium channels in a rat model of acute subdural hematoma.
Nakagawa I et al (2013) J Clin Neurosci 20(1) : 144-7.PubMedID: 23036174
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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