你好生物/二氮嗪/HB0244/500mg
商品编号：
HB0244-500mg
品牌：
hellobio
市场价：
¥1189.50
美元价：
915.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameDiazoxide
- ShortdescriptionSelectiveKIR6activator
- BIOLOGicaldescriptionSelectiveKIR6(ATP-sensitiveK+)channelactivator.IncreasesEPSCstoaround150%ofcontrolvalues.ShowscardioprotectiveactionsduringischaemicinjurybyactivatingPKCε.Alsoshowsneuroprotectiveandantihypertensiveactions.
- BiologicalactionActivator
- Purity>98%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname7-Chloro-3-methyl-2H-1,2,4-benzothiADIazine1,1-dioxide
- MolecularWeight230.67
- Chemicalstructure
![Diazoxide [364-98-7]](images/hellobio/201710/hb0244.png "Diazoxide [364-98-7]")
- MolecularFormulaC8H7ClN2O2S
- CASNumber364-98-7
StoringandUsingYourProduct
- Storageinstructionsroomtemperature
- SolubilityoverviewsolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforDiazoxide
Diazoxideblocksglutamatedesensitizationandprolongsexcitatorypostsynapticcurrentsinrathippocampalneurons.
YamadaKAetal(1992)JPhysiol458:409-23.PubMedID:1302270DiazoxideactsmoreasaPKC-epsilonactivator,andindirectlyactivatesthemitochondrialK(ATP)channelconferringcardioprotectionagainsthypoxicinjury.
KimMYetal(2006)BrJPharmacol149(8):1059-70.PubMedID:17043673TowardsselectiveKir6.2/SUR1potassiumchannelopeners,medicinalchemistryandtherapeuticperspectives.
HansenJB(2006)CurrMedChem13(4):361-76.PubMedID:16475928TheneuroprotectiveeffectofdiazoxideismediatedbymitochondrialATP-dependentpotassiumchannelsinaratmodelofacutesuBDuralhematoma.
NakagawaIetal(2013)JClinNeurosci20(1):144-7.PubMedID:23036174
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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