Productoverview

• Name
  Dexamethasone(water-soluble)
• Shortdescription
  Syntheticglucocorticoidwithpotentanti-inflammatoryactions.InduceshMSCdifferentiation.Watersolubleandsuitableforcellculture.
• BIOLOGicaldescription

  Syntheticglucocorticoidwhichshowspotentanti-inflammatoryandimmunospressanteffects.

  Inducesdifferentiationofmesenchymalstemcells(hMSCs)intoADIpogenic,chondrogenicandosteogeniclineages.

  Commonlyusedwithascorbicacidandβ-Glyforosteogenicdifferentiationofstemcells.

  
  Thisisawatersolublecompoundcomposedofadexamethasone–Cyclodextrincomplex(Approx.65mgdexamethasonepergm.Balance2-hydroxypropyl-β-cyclodextrin).

  Dexamethasonefreebasealsoavailable.

• Biologicalaction
  AgoNIST
• Purity
  >98%
• Ourproductsinaction
  SubmitYourCitationNow

Properties

• Chemicalname
  (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
• MolecularWeight
  6190.85
• Chemicalstructure
  
• CASNumber
  50-02-2
• PubChemidentifier
  71308592
• SMILES
  CC1CC2C3CCC4=CC(=O)C=CC4(C3C(CC2(C1C(=O)CO)C)O)C.C(C1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(C(C7O)O)OC8C(OC(O2)C(C8O)O)CO)CO)CO)CO)CO)CO)O)O)O
• InChi
  InChI=1S/C42H70O35.C22H30O4/c43-1-8-29-15(50)22(57)36(64-8)72-30-9(2-44)66-38(24(59)17(30)52)74-32-11(4-46)68-40(26(61)19(32)54)76-34-13(6-48)70-42(28(63)21(34)56)77-35-14(7-49)69-41(27(62)20(35)55)75-33-12(5-47)67-39(25(60)18(33)53)73-31-10(3-45)65-37(71
• InChiKey
  XEJNDGTUKUMQNG-ARJMFYCQSA-N
• MDLnumber
  MFCD00064136
• Appearance
  Whitetooff-whitesolid
• Formulation
  Approximately65mgdexamethasonepergm.Balance2-hydroxypropyl-β-cyclodextrin.

StoringandUsingYourProduct

• Storageinstructions
  -20°C.Protectfromlight.
• Solubilityoverview
  Solubleinwater(100mM)
• Important
  ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforDexamethasone(water-soluble)

• Dexamethasonealleviatestumor-associatedbraindamageandangiogenesis.

  FanZetal(2014)PLoSOne9(4):e93264.

  PubMedID:24714627

• GlucocorticoidreceptorantagonismbycyproteroneacetateandRU486.

  HonerCetal(2003)MolPharmacol63(5):1012-20.

  PubMedID:12695529

• Shortboutsofmechanicalloadingareaseffectiveasdexamethasoneatinducingmatrixproductionbyhumanbonemarrowmesenchymalstemcell.

  SittichokechaiwutAetal(2010)EurCellMater20:45-57.

  PubMedID:20648425