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Hello Bio/Clozapine N-oxide (CNO) (water soluble)/HB1807/100mg
Productoverview
- NameClozapineN-oxide(CNO)(watersoluble)
- ShortdescriptionWatersolubleprototypicalDREADDactivator.Clozapinemetabolite.
- BIOLOGicaldescription
ClozapineN-oxide(CNO)istheprototypicalchemicalactuatorforGq-DREADDs.Itisametaboliteoftheatypicalantipsychoticclozapine.
‘Excitatory’Gq-coupled)DREADDs:CNOactivatestheexcitatoryGq-coupledDREADDs:hM3Dq,hM1DqandhM5Dq.
ThehM3DqDREADDistypicallyusedforenhancingneuronalfiringandactivating(Gq-signalinginneuronalandnon-neuronalcells.
‘Inhibitory’(Gi-coupled)DREADDs:
CNOalsoactivatestheinhibitoryhM4DiandhM2DiGi-coupledDREADDs.
ThehM4DiDREADDisthemostcommonlyusedinhibitoryDREADDandisusedforneuronalsilencing.
Gsandβ-arrestincoupledDREADDs:
CNOalsoactivatestheGs-coupledDREADD(GsD)andtheβ-arrestinpreferringDREADD:rM3Darr(Rq(R165L).
CNOcanbeadmiNISTeredintraperitoneally(i.p.),subcutaneously,directlyinfusedintracranially,viadrinkingwaterorosmoticmini-pump.SeeourTechnicalreview(table3)forexampleadministrationmethodsanddoses.
RecentfindingssuggestthatsystemicallyadministeredCNOdoesnotreADIlycrosstheblood-brain-barrierinvivo,andconvertstoclozapinewhichactivatesDREADDs.Caremustbetakeninexperimentaldesignandpropercontrolsshouldbeincorporated. - AlternativenamesCNO
- BiologicalactionActivator
- Purity>98%
- Customercomments
YourtechnicalreviewonCNOstABIlity,solubilityanduseinthelabhasbeenreallyhelpfultomygroup.Verifiedcustomer
TheClozapineN-oxide(CNO)workedperfectly!ItdissolvedcompletelyinsalineatthedoseIamusingsonoproblemsthere!Verifiedcustomer,IstitutoItalianodiTecnologia
TheclozapineN-oxidedissolvesperfectlyinsaline,evenatahighdose!Verifiedcustomer,RadboudUniversity
- OurproductsinactionSubmitYourCitationNow
Images
Properties
- Chemicalname8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
- MolecularWeight342.82
- Chemicalstructure
- MolecularFormulaC18H19ClN4O
- CASNumber34233-69-7
- PubChemidentifier2819
- SMILESC[N+]1(CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl)[O-]
- SourceSynthetic
- InChiInChI=1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h4-7,12,21H,8-11H2,1H3
- InChiKeyWYRDWWAASBTJLM-UHFFFAOYSA-N
- MDLnumberMFCD00210190
- AppearanceYellowsolid
Applications
- Applicationnotes
Non-CNODREADDactivators- Compound21(DREADDagonist21)hydrochloridehasminimaloff-targetactivityandisnotmetabolizedtoclozapine.ThefreebaseCompound21(DREADDagonist21)isalsoavailable.
- ThepotentandselectivehM3DqDREADDagonistPerlapinehydrochloride(watersoluble)andPerlapinearealsoavailable.
- SalvinorinB(SALB)SalvinorinB(SALB)whichpotentlyactivatestheinhibitoryKORDDREADDtoinduceneuronalinhibitionisalsoavailable.
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature(desiccate)
- SolubilityoverviewSolubleinwater(100mM)
- Handling
Duringsolubilitytesting,precipitationwasfoundtooccurinsomeconcentrated(100mM)samples.
WethereforerecommendmakingupsolutionsandusingonsamedayifpossIBLe.Makingandhandlingofsolutionsshouldbeconductedinadustfreeenvironmentandensurethatproductandsolventsareatambienttemperaturebeforeuse.Pleasetakecaretoensurethatyourproductiscompletelydissolvedbeforeuse.Formoreinformation,readourreviewClozapineN-Oxide(watersoluble)-atechnicalreviewonstability,solubilityanduseinthelab.Itincludesdataonsolubility,storageandhandling,includingresultsfromourin-housetests,andguidelinesonuseinthelab,invivoandinvitro.
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforClozapineN-oxide(CNO)(watersoluble)
NoveldesignerreceptorstoprobeGPCRsignalingandphysiology.
Wessetal(2013)TrendsPharmacolSci.34(7):385-92PubMedID:23769625EvolvingthelocktofitthekeytocreateafamilyofGprotein-coupledreceptorspotentlyactivatedbyaninertligand.
Arbrusteretal(2007)ProcNatlAcadSciUSA.104(12):5163-8PubMedID:17360345TheroleofM1muscarinicreceptoragonismofN-desmethylclozapineintheuniqueclinicaleffectsofclozapine.
Weineretal(2004)Psychopharmacology(Berl).177(1-2):207-16PubMedID:15258717Achemical-geneticapproachtostudyGproteinregulationofbetacellfunctioninvivo.
Guettieretal(2009)ProcNatlAcadSciUSA106(45):19197-202PubMedID:https://www.ncbi.nlm.nih.gov/pub