你好Bio/Clozapine/HB1607/50mg
商品编号：
HB1607-50mg
品牌：
hellobio
市场价：
¥1053.00
美元价：
810.00
产品分类：
酸碱缓冲液
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Productoverview
- NameClozapine
- ShortdescriptionPrototypic,atypicalantipsychotic,bindstobothSEROtoninanddopaminereceptors
- BIOLOGicaldescription
Prototypic,atypicalantipsychotic,bindstobothserotoninanddopaminereceptors(Kivaluesare35,83and22,250and141nMatD2,D3andD4,D5,D1and12.6and13.2nMat5-HT2Aand5-HT2Creceptorsrespectively).Alsoshowsactivityatotherreceptors.
Showsantisychotic,antidepressionandanxiolyticactivites.Activeinvivo.
RecentlyindicatedtoshowhighDREADD(hM3Dq/hM4Di)affinityandpotency.
- BiologicalactionAgoNIST
- Purity>99%
- OurproductsinactionSubmitYourCitationNow
Properties
- Chemicalname8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
- MolecularWeight326.83
- Chemicalstructure
![Clozapine [5786-21-0]](images/hellobio/201710/hb1607.png "Clozapine [5786-21-0]")
- MolecularFormulaC18H19ClN4
- CASNumber5786-21-0
- PubChemidentifier2818
- SMILESCN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
- InChiInChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h4-7,12,21H,8-11H2,1H3
- InChiKeyZUXABONWMNSFBN-UHFFFAOYSA-N
- MDLnumberMFCD00153785
StoringandUsingYourProduct
- StorageinstructionsRoomtemperature
- SolubilityoverviewSolubleinDMSO(100mM)
- ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.
ReferencesforClozapine
Antipsychoticdrugs:importanceofdopaminereceptorsformechanismsoftherapeuticactionsandsideeffects.
StrangePG(2001)PharmacolRev53(1):119-33.PubMedID:11171942CloningofthegeneforahumandopamineD5receptorwithhigheraffinityfordopaminethanD1.
SunaharaRKetal(1991)Nature350(6319):614-9.PubMedID:1826762Differentialregulationofrat5-HT2Aand5-HT2Creceptorsafterchronictreatmentwithclozapine,chlorpromazineandthreeputativeatypicalantipsychoticdrugs.
Kuoppamã?kiMetal(1995)Neuropsychopharmacology13(2):139-50.PubMedID:8597525
品牌介绍
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。热销产品线：酶抑制剂和激动剂ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。 离子通道调节剂NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。信号通路工具各种信号通路抑制剂、激动剂表观遗传学研究工具potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等受体配体novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等干细胞调节剂ROCK inhibitor Y-27632, SB 431542 DAPT.
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